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On 20 June hrs Marein Schimmel will phd thesis cell culture her thesis 'Sickle cell disease: pathogenesis and biomarkers' at the University of Amsterdam. Promotores : Prof DPM Brandjes MD PhD and prof MHJ van Oers MD PhD Copromotores: BJ Biemond PhD and prof SS Zeerleder MD PhD.
Sickle cell disease SCD is a monogenetic disease wherein the haemoglobin complex of erythrocytes is affected, resulting in sickle haemoglobin. Sickle cell patients suffer from haemolytic anaemia, phd thesis cell culture painful micro -vascular occlusions, secondary organ damage and early death.
The pathophysiology of vaso-occlusive crises VOC includes neutrophil and endothelial activation, increased cellular adhesion and coagulation activation. The aim of the research presented in this thesis was to study clinical biomarkers that may help identification of patients at risk of development of SCD related complications as these are lacking, but required to improve their clinical management.
In two of the clinical observational cohort studies that we executed, plasma levels of nucleosomes were found to have high potential to identify patients in VOC at risk of development of a serious VOC related phd thesis cell culture, acute chest syndrome.
The observed relation between levels of nucleosomes and neutrophil activation markers in plasma of patients with VOC in these studies might be an indication for the presence of Neutrophil Extracellular Traps NET. In a subsequent experimental study we found sera of sickle cell patients able to induce NET formation in neutrophils from healthy donors. Iron chelation was effective to prevent NET formation in a subset of sickle cell sera.
In addition, this thesis includes two prospective longitudinal cohort studies in which we aimed to identify biomarkers related to the development of SCD related long-term organ complications and mortality, phd thesis cell culture. Phd thesis cell culture, the studies described in these thesis may help the identification of new potential targets of therapy for sickle cell patients. Return Overview: Next generation sequencing Available tests About next generation sequencing.
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Return Overview: Portfolio. Return Overview: Spin-Offs. Return Overview: Meet the team. Research PhD theses Marein Schimmel. Thesis Marein Schimmel. On 20 June hrs Marein Schimmel will defend her thesis 'Sickle cell disease: pathogenesis and biomarkers' at the University of Amsterdam Promotores : Prof DPM Brandjes MD PhD and prof MHJ van Oers MD PhD Copromotores: BJ Biemond PhD and prof SS Zeerleder MD PhD Venue: Agnietenkapel, Oudezijds VoorburgwalAmsterdam Summary Sickle cell disease SCD is a monogenetic disease wherein the haemoglobin complex of erythrocytes is affected, phd thesis cell culture, resulting in sickle haemoglobin.
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